Ppc-1

Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities[1][2][3][4].

Product Specifications

CAS Number

[1245818-17-0]

UNSPSC

12352005

Target

Bacterial; Interleukin Related; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ppc-1.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=NC2=C(OC/C=C(C)/C)C=CC=C2C(OC)=C1)OC/C=C(C)\C

Molecular Formula

C21H25NO4

Molecular Weight

355.43

References & Citations

[1]Suzuki T, et al. Weight loss by Ppc-1, a novel small molecule mitochondrial uncoupler derived from slime mold. PLoS One. 2015 Feb 10;10 (2) :e0117088.|[2]Ogura M, et al. Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2. Biochem Pharmacol. 2016 Apr 1;105:55-65.|[3]Haruhisa Kikuchi a, et al. Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds. Tetrahedron 66 (2010) 6000-6007.|[4]Azelmat J, et al. Antibacterial and Anti-inflammatory Activities of Ppc-1, Active Principle of the Cellular Slime Mold Polysphondylium pseudo-candidum. Med Chem. 2015;11 (7) :666-9.