Phthalic acid

Phthalic acid is the final common metabolite of phthalic acid esters (PAEs) . Phthalic acid can be used for the synthesis of synthetic agents, such as isophthalic acid (IPA), and terephthalic acid (TPA) . Phthalic acid has applications in the preparation of phthalate ester plasticizers. Phthalic acid exhibits mutagenic effect and causes genetic damage in mammalian germ cells[1][2][3].

Product Specifications

CAS Number

[88-99-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Biochemical Assay Reagents; Estrogen Receptor/ERR; Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others; Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/phthalic-acid.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(C1=CC=CC=C1C(O)=O)=O

Molecular Formula

C8H6O4

Molecular Weight

166.13

Precautions

H315, H319, H335

References & Citations

[1]Du Yeon Bang, et al.Toxicological Characterization of Phthalic Acid. Toxicol Res 2011;27:191−203|[2]Jha AM, et al., Germ cell mutagenicity of phthalic acid in mice. Mutat Res. 1998 Dec 3;422 (2) :207-12.|[3]Pavan B, et al., Phthalic acid mimics 17beta-estradiol actions in WISH cells. Toxicol Lett. 2001 Jan 3;118 (3) :157-64.|[4]Bai R, et al., Phthalic acid induces oxidative stress and alters the activity of some antioxidant enzymes in roots of Malus prunifolia. J Chem Ecol. 2009 Apr;35 (4) :488-94.