Sonidegib metabolite M48

Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer Tmax (60 h) than Sonidegib[1].

Product Specifications

CAS Number

[1221722-10-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sonidegib-metabolite-m48.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C(O)C1=C(C(C2=CC=C(C=C2)OC(F)(F)F)=CC=C1)C

Molecular Formula

C15H11F3O3

Molecular Weight

296.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Markus Zollinger, et al. Absorption, distribution, metabolism, and excretion (ADME) of ¹⁴C-sonidegib (LDE225) in healthy volunteers. Cancer Chemother Pharmacol. 2014 Jul;74 (1) :63-75.