Apigenin
Protein kinase inhibitor
Product Specifications
Background
Apigenin induces a process called autophagia (1). It is a potent inhibitor of CYP2C9, an enzyme responsible for the metabolism of many pharmaceutical drugs in the body (2). Apigenin has also been shown to reverse the adverse effects of cyclosporine (3).
CAS Number
520-36-5
Product Name Alternative
5,7-Dihydroxy-2- (4-hydroxyphenyl) -4H-chromen-4-one
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
>98%
Weight
0.05
Format
White Solid
Solubility
Soluble to 50 mM in DMSO
Molecular Formula
C15H10O5
Molecular Weight
270.2
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Ruela-de-Sousa R.R., et al. (2010) Cell Death and Disease. 1(e19): 1-11.
2. Dayong S.I., et al. (2009) Drug Metabolism and Disposition. 37(3): 629-634.
3. Chakravarthi S., Wen C.F., Nagaraja H.S. (2009) J Anal Bio Sci. 32(4): 320-327.
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