(R) -Bromoenol lactone

(R) -Bromoenol lactone ((R) -BEL) is an irreversible, chiral, mechanism-based inhibitor of calcium-independent phospholipase γ (iPLA2γ) . (R) -BEL inhibits human recombinant iPLA2γ with an IC50 of approximately 0.6 µM[1].

Product Specifications

CAS Number

[478288-90-3]

Product Name Alternative

(R, E) -Bromoenol lactone

UNSPSC

12352005

Target

Phospholipase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/r-bromoenol-lactone.html

Solubility

10 mM in DMSO

Smiles

O=C1[C@@H](C2=C3C=CC=CC3=CC=C2)CC/C(O1)=C\Br

Molecular Formula

C16H13BrO2

Molecular Weight

317.18

References & Citations

[1]Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J Biol Chem. 2002 Sep 6;277 (36) :32807-14.