DENV-IN-4
DENV-IN-4 is a potent DENV inhibitor (DENV EC50=4.79 μM, Vero CC50>100 μM, SI>20.9) . DENV-IN-4 can inhibit the expression level of DENV2 with concentration-dependence and reduce RNA-dependent RNA polymerase (RdRp) enzymatic activity. DENV-IN-4 has antiviral effect[1].
Product Specifications
CAS Number
2762302-75-8
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/denv-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C1[C@@](CC2=CC=CC=C23)([H])N3[C@](C4=CC=C(C=C4)O[Si](C)(C)C(C)(C)C)([H])N1NC5=CC=C(C=C5)[N+]([O-])=O
Molecular Formula
C28H32N4O4Si
Molecular Weight
516.66
References & Citations
[1]Qian W, et al. Design, synthesis, discovery and SAR of the fused tricyclic derivatives of indoline and imidazolidinone against DENV replication and infection [published online ahead of print, 2022 Jan 24]. Bioorg Chem. 2022;120:105639.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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