Nothofagin
Nothofagin, a dihydrochalcone, is isolated from rooibos (Aspalathus linearis) [1]. Nothofagin downregulates NF-κB translocation through blocking calcium influx. Nothofagin has antioxidant activity and ameliorates various inflammatory responses such as the septic response and vascular inflammation[2].
Product Specifications
CAS Number
11023-94-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Calcium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nothofagin.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
OC1=C([C@@H]([C@@H]([C@H]2O)O)O[C@@H]([C@H]2O)CO)C(O)=CC(O)=C1C(CCC(C=C3)=CC=C3O)=O
Molecular Formula
C21H24O10
Molecular Weight
436.41
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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