CU-CPT-9a
CU-CPT-9a is a specific TLR8 antagonist, with an IC50 of 0.5 nM.
Product Specifications
CAS Number
[2165340-32-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/CU-CPT-9a.html
Purity
99.74
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=C(C)C=C(C=C1)C2=CC=NC3=CC(OC)=CC=C32
Molecular Formula
C17H15NO2
Molecular Weight
265.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang S, et al. Small-molecule inhibition of TLR8 through stabilization of its resting state. Nat Chem Biol. 2018 Jan;14 (1) :58-64.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR8
Available Sizes
Curated Selection
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