12-HETE-d8
12-HETE-d8 is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3].
Product Specifications
CAS Number
2525175-25-9
UNSPSC
12352211
Target
Apoptosis
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Concentration
304.40 μM * 250 μL in Acetonitrile
Purity
98.0
Solubility
10 mM in DMSO
Smiles
CCCCC/C([2H])=C(CC([2H])(/C([2H])=C/C([2H])=C(C/C([2H])=C(CCCC(O)=O)/[2H])/[2H])O)/[2H]
Molecular Formula
C20H24D8O3
Molecular Weight
328.52
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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