Cis-Urocanic acid-13C3

Cis-Urocanic acid-13C3 is the 13C-labeled cis-Urocanic acid. cis-Urocanic acid is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM) . cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor[1].

Product Specifications

Product Name Alternative

(Z) -Urocanic acid-13C3; cis-UCA-13C3

UNSPSC

12352005

Target

5-HT Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cis-urocanic-acid-13c3.html

Purity

99.46

Solubility

H2O : 50 mg/mL (ultrasonic; warming)

Smiles

O=[13C](O)/[13C]=[13C]\C1=CN=CN1

Molecular Formula

C3 13C3H4N2O2

Molecular Weight

139.09

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Walterscheid JP, et al. Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor. Proc Natl Acad Sci U S A. 2006 Nov 14;103 (46) :17420-5.|[3]Viiri J, et al. Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro. Mol Vis. 2009 Sep 8;15:1799-805.