TCO-OH
TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
Product Specifications
CAS Number
[85081-69-2]
UNSPSC
12352211
Hazard Statement
H318, H412
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tco-oh.html
Purity
99.91
Solubility
10 mM in DMSO
Smiles
OC1CC/C=C/CCC1
Molecular Formula
C8H14O
Molecular Weight
126.20
Precautions
H318, H412
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Alkyl-Chain Linkers
Available Sizes
Curated Selection
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