TCO-OH

TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

Product Specifications

CAS Number

[85081-69-2]

UNSPSC

12352211

Hazard Statement

H318, H412

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tco-oh.html

Purity

99.91

Solubility

10 mM in DMSO

Smiles

OC1CC/C=C/CCC1

Molecular Formula

C8H14O

Molecular Weight

126.20

Precautions

H318, H412

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562