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Bis-PEG2-PFP ester

Bis-PEG2-PFP ester is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. Bis-PEG2-PFP ester is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

Product Specifications

CAS Number

1314378-18-1

UNSPSC

12352203

Hazard Statement

H302-H315-H319-H335

Target

ADC Linker; PROTAC Linkers

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bis-peg2-pfp-ester.html

Solubility

10 mM in DMSO

Smiles

O=C(OC1=C(F)C(F)=C(F)C(F)=C1F)CCOCCOCCC(OC2=C(F)C(F)=C(F)C(F)=C2F)=O

Molecular Formula

C20H12F10O6

Molecular Weight

538.29

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Matthew David DOROSKI, et al. Cytotoxic peptides and antibody drug conjugates thereof. WO2013072813A2.|[2]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Shipping Conditions

Room temperature

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Alkyl/ether Linkers; Non-cleavable Linker; PEG Linkers

Available Sizes

Frequently Asked Questions

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