NPD10084
NPD10084 is a pyruvate kinase PKM2 inhibitor that inhibits non-glycolytic signaling in cancer cells. NPD10084 disrupts the interaction between PKM2 and β-catenin or STAT3 and inhibits downstream signaling. NPD10084 has antiproliferative activity against colorectal cancer cells in vitro and in vivo[1].
Product Specifications
CAS Number
[1040706-91-9]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Pyruvate Kinase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/npd10084.html
Purity
99.69
Solubility
DMSO : ≥ 100 mg/mL
Smiles
COC1=CC=CC2=C1C=C(C(N3CCC4=C(C5=CC=CC=C5N4)C3)=O)N2
Molecular Formula
C21H19N3O2
Molecular Weight
345.39
Precautions
H315, H319, H320
References & Citations
[1]Nagasawa I, et al. Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA. Cell Chem Biol. 2020 Feb 20;27 (2) :186-196.e4.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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