CRT5

CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively) . CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis[1].

Product Specifications

CAS Number

[1034297-58-9]

Product Name Alternative

CRT0066051

UNSPSC

12352005

Target

PKD

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/crt5.html

Purity

98.70

Solubility

10 mM in DMSO

Smiles

O=C(NCCN(C)C)C1=CC=CC(C2=CC(C3=CC=C4C=C(OCC)C=CC4=C3)=C(N)N=C2)=C1

Molecular Formula

C28H30N4O2

Molecular Weight

454.56

References & Citations

[1]Evans IM, et al. Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochem J. 2010 Aug 1;429 (3) :565-72.