CRT5
Product Specifications
UNSPSC Description
CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis[1].
Target Antigen
PKD
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/crt5.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCN(C)C)C1=CC=CC(C2=CC(C3=CC=C4C=C(OCC)C=CC4=C3)=C(N)N=C2)=C1
Molecular Weight
454.56
References & Citations
[1]Evans IM, et al. Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochem J. 2010 Aug 1;429(3):565-72.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112547/CRT5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112547/
Clinical Information
No Development Reported
CAS Number
1034297-58-9
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