MK-0736
MK-0736 (Compounds 1) is highly potent and selective inhibitor of 11β-HSD1. MK-0736 can be used for the research of type 2 diabetes, hypertension and metabolic syndrome[1].
Product Specifications
CAS Number
[719272-79-4]
UNSPSC
12352005
Target
11β-HSD
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/MK-0736.html
Solubility
10 mM in DMSO
Smiles
FC(C1=CC=CC=C1C2=NN=C(C3(CC4)CCC4(CCCS(=O)(CC)=O)CC3)N2C)(F)F
Molecular Formula
C23H30F3N3O2S
Molecular Weight
469.56
References & Citations
[1]Sukrut Shah, et al. Efficacy and safety of the selective 11β-HSD-1 inhibitors MK-0736 and MK-0916 in overweight and obese patients with hypertension. J Am Soc Hypertens. 2011 May-Jun;5 (3) :166-76. |[2]Bauman DR, et al. Evaluation of selective inhibitors of 11β-HSD1 for the treatment of hypertension. Bioorg Med Chem Lett. 2013 Jun 15;23 (12) :3650-3.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-112290/MK-0736-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-112290/
Scientific Category
Reference compound1
Clinical Information
Phase 2
Curated Selection
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