ZZW-115

ZZW-115 is a potent NUPR1 inhibitor, with a Kd of 2.1 μM. ZZW-115 induces tumor cell death by necroptosis and apoptosis. Anticancer activity[1][2].

Product Specifications

CAS Number

[801991-87-7]

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/zzw-115.html

Purity

99.88

Solubility

10 mM in DMSO

Smiles

FC(C(C=C1N2CCCN3CCN(CCN(C)C)CC3)=CC=C1SC4=C2C=CC=C4)(F)F

Molecular Formula

C24H31F3N4S

Molecular Weight

464.59

References & Citations

[1]Santofimia-Castaño P, et al. Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis. J Clin Invest. 2019;129 (6) :2500-2513. Published 2019 Mar 28.|[2]Santofimia-Castaño P, et al. Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma. Cells. 2019;8 (11) :1453. Published 2019 Nov 17.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Research Square Preprint. 2024 Feb 20.|BMC Med. 2022 Oct 19;20 (1) :365.|J Cell Mol Med. 2025 Apr;29 (7) :e70519.|Mol Cancer. 2024 May 28;23 (1) :113.