(±) -PPCC (oxalate)
(±) -PPCC oxalate is a sigma-1 agonist that mainly interacts with sigma-1 receptors with Ki of 1.5 nM. (±) -PPCC oxalate has effective anti-amnesia effects in rats with mild or severe cognitive impairment, and can improve the cognitive abilities of rats[1].
Product Specifications
CAS Number
1781628-91-8
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/racemic-ppcc-oxalate.html
Solubility
10 mM in DMSO
Smiles
OC(C(O)=O)=O.COC([C@]1(C2=CC=C(C=C2)C)[C@@H](C1)CN3CCC(CC3)(C4=CC=CC=C4)O)=O
Molecular Formula
C26H31NO7
Molecular Weight
469.53
References & Citations
[1]Antonini V, et al. Anti-amnesic properties of (+/-) -PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J Neurochem. 2009 May;109 (3) :744-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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