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HIV-1 inhibitor-61

HIV-1 inhibitor-61 (2c) is a HIV-1 reverse transcriptase inhibitor, with an EC50 of 0.07 nM in NL4-3 wt MT-4 cells[1].

Product Specifications

CAS Number

[1114507-62-8]

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hiv-1-inhibitor-61.html

Solubility

10 mM in DMSO

Smiles

O=C1NC(SC[C@H]2[C@H](C3=CC=C(OC)C=C3)C2)=NC([C@@H](C4=C(F)C=CC=C4F)C)=C1C

Molecular Formula

C24H24F2N2O2S

Molecular Weight

442.52

References & Citations

[1]Marco Radi, et al. Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (S-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants. J Med Chem. 2009 Feb 12;52 (3) :840-51.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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