Gusperimus
Gusperimus is a fully synthetic racemate that has a novel mechanism of action by binding to the intracellular heat shock protein hsp70 and interfering with intracellular signal transduction. This mechanism of action can enhance the effect of immunosuppressive therapy. Gusperimus can inhibit the differentiation of T cells into cytotoxic T cells, reduce the expression of IL-2 receptors on CD4 and CD8 cells, and inhibit IFN-γ-induced B cell maturation. In addition, when used with cyclosporine, tacrolimus or mycophenolate mofetil, Gusperimus can enhance the immunosuppressive effect and prevent allogeneic transplant rejection.
Product Specifications
CAS Number
[98629-43-7]
Product Name Alternative
15-Deoxyspergualin
UNSPSC
12352211
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/gusperimus.html
Smiles
O=C(NC(O)C(NCCCCNCCCN)=O)CCCCCCNC(N)=N
Molecular Formula
C17H37N7O3
Molecular Weight
387.52
References & Citations
[1]Mechanisms of Action of Immuno suppressants and Immunoinductors
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
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