Gusperimus
Product Specifications
UNSPSC Description
Gusperimus is a fully synthetic racemate that has a novel mechanism of action by binding to the intracellular heat shock protein hsp70 and interfering with intracellular signal transduction. This mechanism of action can enhance the effect of immunosuppressive therapy. Gusperimus can inhibit the differentiation of T cells into cytotoxic T cells, reduce the expression of IL-2 receptors on CD4 and CD8 cells, and inhibit IFN-γ-induced B cell maturation. In addition, when used with cyclosporine, tacrolimus or mycophenolate mofetil, Gusperimus can enhance the immunosuppressive effect and prevent allogeneic transplant rejection.
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/gusperimus.html
Smiles
O=C(NC(O)C(NCCCCNCCCN)=O)CCCCCCNC(N)=N
Molecular Weight
387.52
References & Citations
[1]Mechanisms of Action of Immunosuppressants and Immunoinductors
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13644/Gusperimus-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13644/
Clinical Information
Phase 3
CAS Number
98629-43-7
Curated Selection
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