TC-G 24

TC-G 24 (Compound 24) is a potent, selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 17.1 nM. TC-G 24 can cross the BBB and can be used for studying many diseases such as type 2 diabetes mellitus, stroke, Alzheimer, and other related diseases[1].

Product Specifications

CAS Number

[1257256-44-2]

UNSPSC

12352005

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/tc-g-24.html

Solubility

10 mM in DMSO

Smiles

O=[N+](C1=CC=C(C2=NN=C(NC3=CC=C(C)C(Cl)=C3)O2)C=C1)[O-]

Molecular Formula

C15H11ClN4O3

Molecular Weight

330.73

References & Citations

[1]Khanfar MA, et al. Discovery of novel GSK-3β inhibitors with potent in vitro and in vivo activities and excellent brain permeability using combined ligand- and structure-based virtual screening. J Med Chem. 2010 Dec 23;53 (24) :8534-45.|[2]Lihui Wang, et al. FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping. Cell Metab. 2020 Nov 3;32 (5) :860-877.e9.