(R, S) -3,4-Dicarboxyphenylglycine

(R, S) -3,4-Dicarboxyphenylglycine ((RS) -3,4-DCPG) is an AMPA receptor antagonist. (R, S) -3,4-Dicarboxyphenylglycine antagonizes AMPA-mediated depolarization of motor neurons in neonatal rats. (R, S) -3,4-Dicarboxyphenylglycine can be used in the study of neurological diseases[1].

Product Specifications

CAS Number

[176796-64-8]

Product Name Alternative

(R, S) -3,4-DCPG

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-s-3-4-dicarboxyphenylglycine.html

Solubility

10 mM in DMSO

Smiles

OC(C1=C(C=CC(C(N)C(O)=O)=C1)C(O)=O)=O

Molecular Formula

C10H9NO6

Molecular Weight

239.18

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Thomas NK, et al. Dicarboxyphenylglycines antagonize AMPA- but not kainate-induced depolarizations in neonatal rat motoneurones. Eur J Pharmacol. 1997 Nov 5;338 (2) :111-6.