Org-24598

Org-24598 is an inhibitor of glycine transporter 1 GlyT-1 . Org-24598 can inhibit the specific binding of [3H] CHIBIA-3007 to the rat brain membranes with a Ki value of 16.9 nM[1].

Product Specifications

CAS Number

[372198-97-5]

UNSPSC

12352005

Target

GlyT

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/org-24598.html

Solubility

10 mM in DMSO

Smiles

CN(CC(O)=O)CC[C@@H](OC1=CC=C(C(F)(F)F)C=C1)C2=CC=CC=C2

Molecular Formula

C19H20F3NO3

Molecular Weight

367.36

References & Citations

[1]Zhang J, et al. Pharmacological characterization of [³H]CHIBA-3007 binding to glycine transporter 1 in the rat brain. PLoS One. 2011;6 (6) :e21322.