Arimoclomol (citrate)
Arimoclomol citrate (BRX-220 citrate) is an orally active co-inducer of heat shock proteins (HSP) [1]. Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system[2]. Arimoclomol citrate can be used for the study of Niemann–Pick disease type C.
Product Specifications
CAS Number
368860-21-3
Product Name Alternative
BRX-220 (citrate)
UNSPSC
12352005
Hazard Statement
H317, H361, H412
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/arimoclomol-citrate.html
Purity
99.76
Solubility
DMSO : 35 mg/mL (ultrasonic)
Smiles
Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2.O=C(CC(C(O)=O)(O)CC(O)=O)O
Molecular Formula
C20H28ClN3O10
Molecular Weight
505.90
Precautions
H317, H361, H412
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HSP
Available Sizes
Frequently Asked Questions
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