Recombinant PD1 Monoclonal Antibody

The programmed cell death 1 protein (PD1) is an inhibitory receptor expressed on antigen activated T-cells that plays a critical role in the induction and maintenance of immune tolerance to self-antigens. Upon binding to its ligands CD274/PDCD1L1 (PD-L1) and CD273/PDCD1LG2 (PD-L2), PD1 is phosphorylated within its immunoreceptor tyrosine-based switch motif (ITSM), which facilitates the recruitment of the protein tyrosine phosphatase PTPN11/SHP-2. PTPN11/SHP-2 then dephosphorylates key T-cell receptor (TCR) proximal signaling molecules, including ZAP70, PRKCQ/PKC theta and CD247/CD3 zeta, leading to the direct inhibition of T-cell activation. The PD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and evade destruction by the immune system, thereby facilitating tumor survival.

SLEB; hSLE; Programmed Death; programmed cell death; Programmed cell death protein; Systemic lupus erythematosus susceptibility; hPD; PDCD1; CD279; PD-1; PD1; SLEB2; hPD-1; hPD-l; hSLE1; programmed cell death 1; PD 1; CD279 antigen; hPD 1; hPD l; PDCD 1; Programmed cell death 1 protein; Programmed Death-1; Protein PD 1; Protein PD-1; Systemic lupus erythematosus susceptibility 2; Programmed cell death protein 1; CD279; CD279 antigen; hPD 1; hPD l; hPD-1; hSLE1; PD 1; PD-1; PD1; PDCD 1; PDCD1; PDCD1; Programmed cell death 1; Programmed cell death 1 protein; Programmed cell death protein 1; Protein PD 1; Protein PD-1; SLEB2; Systemic lupus erythematosus susceptibility 2