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Echinomycin

Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM[1][2].

Product Specifications

Product Name Alternative

Quinomycin A; NSC-13502

UNSPSC

12352005

Hazard Statement

H301, H311, H331, H361

Target

Antibiotic; Bacterial; HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/echinomycin.html

Purity

98.57

Solubility

DMSO : 5.3 mg/mL (ultrasonic)

Smiles

[H]C1=NC2=C(N=C1C(N[C@H](COC([C@H](C(C)C)N(C)C([C@H]3N4C)=O)=O)C(N[C@@H](C)C(N(C)[C@@H]([C@@H](SC)SC3)C(N(C)[C@@H](C(C)C)C(OC[C@@H](NC(C5=NC6=C(C=CC=C6)N=C5[H])=O)C(N[C@@H](C)C4=O)=O)=O)=O)=O)=O)=O)C=CC=C2

Molecular Formula

C51H64N12O12S2

Molecular Weight

1101.26

Precautions

H301, H311, H331, H361

References & Citations

[1]Kong D, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005 Oct 1;65 (19) :9047-55.|[2]Wang Y, et al. Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell. 2011 Apr 8;8 (4) :399-411.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, stored under nitrogen)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-106101/Echinomycin-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-106101/Echinomycin-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

CAS Number

[512-64-1]

Available Sizes

Curated Selection

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