HexylHIBO

HexylHIBO is a potent group I mGluR antagonist with Kbs of 140 μM and 110 μM at mGlu1a and mGlu5a receptors, respectively. HexylHIBO does not inhibits mGlu2 and mGlu4a. HexylHIBO decreased spontaneous excitatory postsynaptic currents (sEPSCs) in rat[1].

Product Specifications

CAS Number

[334887-43-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/hexylhibo.html

Purity

98.0

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C(N)CC(ON1)=C(CCCCCC)C1=O

Molecular Formula

C12H20N2O4

Molecular Weight

256.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Madsen U, et al. Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. J Med Chem. 2001;44 (7) :1051-1059.|[2]Bandrowski AE, et al, Prince DA. Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol. 2003;89 (3) :1308-1316.