Eicosanoyl-5-hydroxytryptamide
A neuroprotective natural product found in coffee
Product Specifications
Background
A natural product found in coffee which synergizes with caffeine in protecting the brain in models of alpha-synucleinopathy (1). It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated alpha-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. It prevents ABeta-induced impairments in mouse models of Alzheimer’s disease (2,3).
Product Name Alternative
Eicosanoyl serotonin; Eicosanoyl-5-hydroxytryptamide; EHT
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau | Synuclein
Purity
>98% (TLC) ; NMR (Conforms)
Weight
0.005
Format
Beige powder
Solubility
May be dissolved in DMSO (30 mg/ml); or ethanol (20 mg/ml, warm)
Molecular Formula
C30H50N2O2
Molecular Weight
470.7
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Yan R., et al. (2018) Proc. Natl. Acad. Sci. USA . 115:E12053
2. Asam K., et al. (2017) PLoS One. 12:e0189413
3. Basurto-Islas G., et al. (2014) Neurobiol. Aging. 35:2701
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