AT9283 (lactic acid)
Product Specifications
UNSPSC Description
AT9283 lactic acid is a multi-targeted kinase inhibitor with potent activity against Aurora A/B, JAK2/3, Abl (T315I) and Flt3 (IC50s ranging from 1 to 30 nM). AT9283 lactic acid inhibits growth and survival of multiple solid tumors in vitro and in vivo[1][2].
Target Antigen
Apoptosis; Aurora Kinase; Autophagy; Bcr-Abl; FLT3; JAK
Type
Reference compound
Related Pathways
Apoptosis;Autophagy;Cell Cycle/DNA Damage;Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/at9283-lactic-acid.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1CC1)NC2=CNN=C2C3=NC(C=C4)=C(C=C4CN5CCOCC5)N3.O=C(O)[C@H](C)O
Molecular Weight
471.51
References & Citations
[1]Howard S, et al. Fragment-Based Discovery of the Pyrazol-4-yl Urea (AT9283), a Multitargeted Kinase Inhibitor with Potent Aurora Kinase Activity. Journal of Medicinal Chemistry (2009), 52(2), 379-388.|[2]Qi W, et al. AT9283, a novel aurora kinase inhibitor, suppresses tumor growth in aggressive B-cell lymphomas. Int J Cancer. 2012 Jun 15;130(12):2997-3005.Front Oncol. 2021 Jun 18;11:656608.|PLoS Pathog. 2022 Jun 13;18(6):e1010620.|Cancers (Basel). 2022 Mar 19;14(6):1575.|Harvard Medical School LINCS LIBRARY|J Adv Res. 2023 Mar 7;S2090-1232(23)00070-X.|Patent. US20180263995A1.|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10058/AT9283-lactic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10058/
Clinical Information
Phase 2
CAS Number
896466-76-5
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