GCHFR Antibody / GFRP
GTP cyclohydrolase I feedback regulatory protein (GFRP) is encoded by the gene GCHFR. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin. GFRP also acts as a mediator for the stimulatory effect of phenylalanine on enzyme activity. L-phenylalanine reverses this inhibition. Cross-linking experiments have shown that GFRP is usually expressed as a homodimer or pentamer.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P30047
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment of human GCHFR protein was used as the immunogen for the GCHFR antibody.
Clonality
Monoclonal
Isotype
IgG2 κ
Clone
GCHFR/7734
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the GCHFR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This GCHFR antibody is available for research use only.
Storage Conditions
Aliquot the GCHFR antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the GCHFR antibody should be determined by the researcher.
Location
Lysosome
Image Legend
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