Eicosapentaenoyl ethanolamide

Eicosapentaenoyl ethanolamide, an omega-3 fatty acid, is one of N-acylethanolamines (NAEs) . Eicosapentaenoyl ethanolamide is cannabinoid CB1/CB2 receptor agonist. Eicosapentaenoyl ethanolamide acts as a metabolic signal. Eicosapentaenoyl ethanolamide inhibits dietary restriction (DR) -induced lifespan extension in wild type animals and suppresses lifespan extension in a TOR pathway mutant[1][2].

Product Specifications

CAS Number

[109001-03-8]

UNSPSC

12352211

Hazard Statement

H225, H319

Target

Cannabinoid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/eicosapentaenoyl-ethanolamide.html

Concentration

144.71 mM * 200 μL in Ethanol

Purity

98.38

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(CCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)NCCO

Molecular Formula

C22H35NO2

Molecular Weight

345.52

Precautions

H225, H319

References & Citations

[1]Mark Lucanic, et al. N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans. Nature. 2011 May 12;473 (7346) :226-9.|[2]Iain Brown, et al. Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines. Carcinogenesis. 2010 Sep;31 (9) :1584-91.