Phospho-AS160 (Thr642) Antibody

Phospho-AS160 (Thr642) Antibody detects endogenous levels of AS160 only when phosphorylated at Thr642.<br>Tissue Specificity: Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis.

[TBC1 domain family member 4; TBC1 domain family member 4; TBC1 domain family member 4; akt substrate of 160 kDa; Acrg embryonic lethality minimal region ortholog; TBC (Tre-2, BUB2, CDC16) domain-containing protein; TBC1 domain family, member 4; Akt substrate of 160 kDa]