FTI-2148
Product Specifications
UNSPSC Description
FTI-2148 is a RAS C-terminal mimetic dual?farnesyl transferase (FT-1)?and?geranylgeranyl transferase-1 (GGT-1)?inhibitor with?IC50s of 1.4 nM and 1.7 μM, respectively[1].
Target Antigen
Farnesyl Transferase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fti-2148.html
Solubility
10 mM in DMSO
Smiles
CSCC[C@@H](C(O)=O)NC(C1=CC=C(CNCC2=CN=CN2)C=C1C3=CC=CC=C3C)=O
Molecular Weight
452.57
References & Citations
[1]Sun J, et al. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.Cancer Res. 1999 Oct 1;59(19):4919-26.|[2]Carrico D, et al.In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability.Bioorg Med Chem. 2004 Dec 15;12(24):6517-26.|[3] Sun J, et al. Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.Cancer Res. 2003 Dec 15;63(24):8922-9.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-118916/FTI-2148-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-118916/
Clinical Information
No Development Reported
CAS Number
251577-09-0
Available Sizes
Curated Selection
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