mSIRK
Product Specifications
UNSPSC Description
mSIRK (G-Protein βγ Binding Peptide) is an cell-permeable activator of ERK1/2, with EC50 of 2.5-5 μM. mSIRK disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange[1].
Target Antigen
ERK
Type
Peptides
Related Pathways
MAPK/ERK Pathway;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
others
Assay Protocol
https://www.medchemexpress.com/msirk.html
Purity
98.03
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(C=C1)=CC=C1C[C@H](NC(CNC([C@H](CC(C)C)NC([C@H]([C@@H](C)CC)NC([C@H](CC(N)=O)NC([C@H](CC(C)C)NC([C@H](C)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H]([C@@H](C)CC)NC([C@H](CO)NC(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C(N2[C@@H](CCC2)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O
Molecular Weight
1948.31
References & Citations
[1]Farida Goubaeva, et al. Stimulation of Cellular Signaling and G Protein Subunit Dissociation by G Protein βγ Subunit-binding Peptides. J Biol Chem. 2003 May 30;278(22):19634-41.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P5985/mSIRK-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P5985/mSIRK-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
593267-11-9
Available Sizes
Curated Selection
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