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Etoperidone (hydrochloride)

Etoperidone hydrochloride, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone hydrochloride shows Kd values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively[1][2].

Product Specifications

CAS Number

[57775-22-1]

UNSPSC

12352005

Target

5-HT Receptor; Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/etoperidone-hydrochloride.html

Smiles

O=C1N(CCCN2CCN(CC2)C3=CC(Cl)=CC=C3)N=C(CC)N1CC.Cl

Molecular Formula

C19H29Cl2N5O

Molecular Weight

414.37

References & Citations

[1]G W Caldwell, et al. Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man. Xenobiotica. 2001 Nov;31 (11) :823-39. |[2]B Cusack, et al. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl) . 1994 May;114 (4) :559-65.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT1 Receptor; mLAG-3; α adrenergic receptor; α-1 microglobulin

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