(Rac) -PDE4-IN-4
(Rac) -PDE4-IN-4 is the diastereomer mixture of PDE4-IN-4. PDE4-IN-4 is a dual M3 (pIC50 = 10.2) antagonist-PDE4 (pIC50 = 8.8) inhibitor for the inhaled research of pulmonary diseases[1].
Product Specifications
UNSPSC
12352005
Target
MAChR; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rac-pde4-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(CNC(C2=CC=CC=C2)C(O[C@H]3CN4CCC3CC4)=O)S1)O[C@H](C5=CC=C(OC)C(OC)=C5)CC6=C(Cl)C=[N+]([O-])C=C6Cl
Molecular Formula
C36H37Cl2N3O7S
Molecular Weight
726.67
References & Citations
[1]Armani E, et al. Discovery of M3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2021;64 (13) :9100-9119.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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