Recombinant Human Dipeptidase 1/DPEP1 Protein (His Tag)
Product Specifications
Background
Dipeptidase 1 (DPEP1) is a kidney membrane enzyme that belongs to the peptidase M19 family. DPEP1 is a homodimer and is inhibited by L-penicillamine. DPEP1 hydrolyzes a variety of dipeptides and is implicated in renal metabolism of glutathione and its conjugates. DPEP1 is responsible for hydrolysis of the beta-lactam ring of antibiotics; such as penem and carbapenem. DPEP1 may play an important role in the regulation of leukotriene activity. DPEP1 expression in cancer is significantly higher than that in normal tissue. However; DPEP1 expression decreased with pathological differentiation; lymph-node and distant metastasis.
Abbreviation
Dipeptidase 1; DPEP1
Synonyms
DPEP1; Dehydropeptidase-I; Dipeptidase 1; MBD1; MDP; Microsomal Dipeptidase; RDP; Renal Dipeptidase; hRDP
UniProt
P16444
Accession Number
P16444
Expression System
HEK293 Cells
Tag
C-His
Sequence
Asp17-Ser385
Field of Research
Cell biology; Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
42.1 kDa
Observed Molecular Weight
41 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, 10% Glycerol, pH 7.4.
Species
Human
Available Sizes
Documents
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