NMS-P515
NMS-P515 is a potent, orally active and stereospecific PARP-1 inhibitor, with a Kd of 16 nM and an IC50 of 27 nM (in Hela cells) . Anti-tumor activity[1].
Product Specifications
CAS Number
1262395-13-0
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nms-p515.html
Purity
98.18
Solubility
DMSO : 3.33 mg/mL (ultrasonic)
Smiles
O=C(N)C1=C2C([C@H](C)N(C3CCN(C4CCCCC4)CC3)C2=O)=CC=C1
Molecular Formula
C21H29N3O2
Molecular Weight
355.47
References & Citations
[1]Papeo G, et al. Discovery of Stereospecific PARP-1 Inhibitor Isoindolinone NMS-P515. ACS Med Chem Lett. 2019 Mar 13;10 (4) :534-538.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1
Available Sizes
Frequently Asked Questions
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