IMR-1
IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth[1].
Product Specifications
CAS Number
310456-65-6
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Notch
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IMR-1.html
Purity
98.95
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(OCC)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC
Molecular Formula
C15H15NO5S2
Molecular Weight
353.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76 (12) :3593-603.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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