HMCEF

HMCEF is an orally active P-selectin inhibitor and inhibits P-selectin expression. HMCEF blocks the interaction between P-selectin and natural ligands, such as PSGL-1. HMCEF inhibits thrombosis and inflammation in mice[1].

Product Specifications

CAS Number

[2002363-68-8]

UNSPSC

12352005

Target

P-selectin

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/hmcef.html

Smiles

O=C(O)[C@H](CC1=CC=CC=C1)NCCC2=NC(CO)=CC3=C2NC4=C3C=CC=C4

Molecular Formula

C23H23N3O3

Molecular Weight

389.45

References & Citations

[1]Wu J, et al. A novel lead of P-selectin inhibitor: Discovery, synthesis, bioassays and action mechanism. Bioorg Med Chem Lett. 2016 Oct 1;26 (19) :4631-4636.