CUR61414

CUR61414 is a novel, potent and cell permeable Hedgehog signaling pathway inhibitor (IC50 =100-200 nM) . CUR61414 is a small-molecule aminoproline class compound and selectively binds to smoothened (Smo) with a Ki value of 44 nM. CUR-61414 can induce apoptosis in cancer cells without affecting neighboring non-tumor cells[1][2].

Product Specifications

CAS Number

[334998-36-6]

Product Name Alternative

CC 122,CC 122 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; Hedgehog; Smo

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cur61414.html

Concentration

10mM

Purity

99.04

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C)(C)CC(N([C@@H]1CN(CC2=CC=C(OCO3)C3=C2)[C@H](C(N4CCNCC4)=O)C1)CC5=CC=CC(OC)=C5)=O

Molecular Formula

C31H42N4O5

Molecular Weight

550.69

Precautions

H301

References & Citations

[1]Williams JA, et al. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.Proc Natl Acad Sci U S A. 2003 Apr 15;100 (8) :4616-21. Epub 2003 Apr 4.|[2]Frank-Kamenetsky M, et al. Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.J Biol. 2002 Nov 6;1 (2) :10.