SOX2 (Embryonic Stem Cell Marker)
Product Specifications
Gene Name
[SOX2]
NCBI Gene ID
6657
Reactivity
Human, Mouse
Storage Conditions
Antibody with azide: store at 2 to 8 degree C.<br>Antibody without azide: store at -20 to -80 degree C.<br>Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Specificity
SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly, SOX2 is associated with aggressive phenotypes of breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker.
Other Gene Names
[SOX2; SOX2; ANOP3; MCOPS3]
Short Name
[SOX2]
Other Product Names
[transcription factor SOX-2; Transcription factor SOX-2; transcription factor SOX-2; SRY-box transcription factor 2]
NCBI GI Number
28195386
NCBI Accession Number
NP_003097.1
NCBI GB Accession Number
NP_003097.1
Uniprot Accession Number
P48431
Available Sizes
Curated Selection
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