Calcitriol (Standard)

Calcitriol (Standard) is the analytical standard of Calcitriol. This product is intended for research and analytical applications. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

Product Specifications

CAS Number

[32222-06-3]

Product Name Alternative

1,25-Dihydroxyvitamin D3 (Standard)

UNSPSC

12352211

Hazard Statement

H300+H310+H330, H372

Target

Drug Metabolite; Endogenous Metabolite; Reference Standards; VD/VDR

Type

Reference Standards

Related Pathways

Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/calcitriol-standard.html

Purity

99.94

Smiles

C=C1[C@H](C[C@@H](C/C1=C/C=C2[C@]3([C@@](C)([C@H](CC3)[C@@H](CCCC(C)(O)C)C)CCC/2)[H])O)O

Molecular Formula

C27H44O3

Molecular Weight

416.64

Precautions

H300+H310+H330, H372

References & Citations

[1]Wang G, et al. Calcitriol Inhibits Cervical Cancer Cell Proliferation Through Downregulation of HCCR1 Expression. Oncol Res. 2014;22 (5-6) :301-9.|[2]Santos-Martínez N, et al. Calcitriol restores antiestrogen responsiveness in estrogen receptor negative breast cancer cells: a potential new therapeutic approach. BMC Cancer. 2014 Mar 29;14:230.|[3]Dong J, et al. Calcitriol restores renovascular function in estrogen-deficient rats through downregulation of cyclooxygenase-2 and the thromboxane-prostanoid receptor. Kidney Int. 2013 Jul;84 (1) :54-63.|[4]Chou CL, et al. Beneficial effects of calcitriol on hypertension, glucose intolerance, impairment of endothelium-dependent vascular relaxation, and visceral adiposity in fructose-fed hypertensive rats. PLoS One. 2015 Mar 16;10 (3) :e0119843.