Lesopitron
Lesopitron (E-4424) is a 5-HT receptor agonist with potent anxiolytic-like effects. Lesopitron inhibits forskolin-stimulated adenylate cyclase activity with an IC50 value of 125 nM[1].
Product Specifications
CAS Number
132449-46-8
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lesopitron.html
Solubility
10 mM in DMSO
Smiles
ClC1=CN(N=C1)CCCCN2CCN(CC2)C3=NC=CC=N3
Molecular Formula
C15H21ClN6
Molecular Weight
320.82
References & Citations
[1]S Haj-Dahmane, et al. Interactions of lesopitron (E-4424) with central 5-HT1A receptors: in vitro and in vivo studies in the rat. Eur J Pharmacol. 1994.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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