HSP110 Antibody (APC)

Rabbit polyclonal to Hsp110 (APC) . Hsp110 belongs to a family of large stress proteins known as the Hsp110/SSE Family. The proteins in this family are the most distantly known relatives of the well studied Hsp70 family. They share 30-33% amino acid identity, mostly in the conserved ATP-binding domain. Hsp110 cooperates with Hsp70 in protein folding in the eukaryotic cytosol. In mammals, Hsp110 is constitutively expressed, but exhibits particularly high levels in the brain. Both Hsp70 and Hsp110 are elevated after cerebral ischemia. Recent studies demonstrate that the protective effects of Hsp110 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of Hsp70. Studies also suggest that Hsp110 can be used in heat shock protein-based cancer immunotherapy..

Product Specifications

Product Name Alternative

HSPH1, HSP110, HSP105, Heat shock protein 105 kDa, Heat shock 110 kDa protein, KIAA0201, Heat shock 105kDa alpha, heat shock 105kDa beta, HSP105A, HSP105B, NY CO 25

UniProt

Q92599

Reactivity

Bovine, Fish, Hamster, Human, Monkey, Mouse, Rat, Sheep, Yeast

Immunogen

Synthetic peptide derived from the sequence of hamster HSP110; sequence identical to human and mouse

Target

HSP110

Clonality

Polyclonal

Conjugation

APC

Field of Research

Cancer Biology, Cell Biology, Protein Biochemistry, Signal Transduction

Purification

Protein A Purified

Concentration

1 mg/ml

Dilution

WB (1:1000), IHC (1:100)

Molecular Weight

110kDa

Storage Conditions

Conjugated antibodies should be stored according to the product label

Notes

For research use only.

Applications Notes

1 μg/ml was sufficient for detection of HSP110 in 10 μg of human cell line mixed lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.