(2R) -Octyl-α-hydroxyglutarate-d17

(2R) -Octyl-α-hydroxyglutarate-d17 ((2R) -Octyl-2-HG-d17) is deuterium labeled (2R) -Octyl-α-hydroxyglutarate (HY-103641) . (2R) -Octyl-α-hydroxyglutarate is a modified form of S-isomer 2-Hydroxyglutarate[1].

Product Specifications

CAS Number

[2748638-78-8]

Product Name Alternative

(2R) -Octyl-2-HG-d17

UNSPSC

12352211

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

OC(CC[C@H](C(OC([2H])(C([2H])(C([2H])(C([2H])(C([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])[2H])[2H])[2H])[2H])=O)O)=O

Molecular Formula

C13H7D17O5

Molecular Weight

277.43

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Sulkowski PL, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologousrecombination and induces PARP inhibitor sensitivity. Sci Transl Med. 2017 Feb 1;9 (375) .