Donepezil N-oxide
Donepezil N-oxide, a metabolite of Donepezil (HY-14566), is human erythrocyte acetylcholinesterase (AChE) inhibitor[1].
Product Specifications
CAS Number
[120013-84-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cholinesterase (ChE) ; Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/donepezil-n-oxide.html
Purity
99.9
Smiles
O=C1C(CC2CC[N+](CC3=CC=CC=C3)([O-])CC2)CC4=C1C=C(OC)C(OC)=C4
Molecular Formula
C24H29NO4
Molecular Weight
395.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Francesca Groppa, et al. Monitoring Plasma Levels of Donepezil, 5-O-Desmethyl-Donepezil, 6-O-Desmethyl-Donepezil, and Donepezil-N-Oxide by a Novel HPLC Method in Patients With Alzheimer Disease. Ther Drug Monit. 2016 Feb;38 (1) :108-13.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
Available Sizes
Curated Selection
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