Rel-Levormeloxifene
Rel-Levormeloxifene (rel-L-Centchroman) is the relative configuration of Levormeloxifene (HY-122359) . rel-Levormeloxifene is a selective estrogen receptor modulator (SERM) . rel-Levormeloxifene inhibits proliferation of leukemia cells with IC50 about 7 μM, arrests cell cycle at G0/G1 phase, and induces apoptosis. rel-Levormeloxifene induces differentation of myelogenesis leukemia, and enhances ROS production in K562 cells[1].
Product Specifications
CAS Number
[31477-60-8]
Product Name Alternative
Rel-L-Centchroman; Ormeloxifene
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis; Estrogen Receptor/ERR; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rel-levormeloxifene.html
Smiles
CC1(C)[C@@H](C2=CC=CC=C2)[C@H](C3=CC=C(OCCN4CCCC4)C=C3)C5=CC=C(OC)C=C5O1
Molecular Formula
C30H35NO3
Molecular Weight
457.60
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Pooja PAL, et al., An anti-leukemic agent useful for inducing differentiation in myeloid leukemia cells. WO2015044950.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
