TLR7 agonist 22
Product Specifications
UNSPSC Description
TLR7 agonist 22 (Compound 11a) emerges as a selective TLR7 agonist with an IC50 value of 25.86 μM. TLR7 agonist 22 inhibits the cellular HBsAg secretion and effectively activates TLR7, thereby inducing the secretion of TLR7-regulated cytokines IL-12, TNF-αand IFN-αin human PBMC cells. TLR7 agonist 22 is a promising for research in the field of developing novel immunomodulatory anti-HBV agents[1].
Target Antigen
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-22.html
Smiles
FC1=C(OCC2=NC(CC(N3CCC4=C3C=CC=C4)=O)=CS2)C=CC=C1
Molecular Weight
368.42
References & Citations
[1]Li S, et al. Exploration of 1-(indolin-1-yl)-2-(thiazol-2-yl)ethan-1-one derivatives as novel anti-HBV agent with potential TLR7 agonist 22onistic effect. Eur J Med Chem. 2024 Jun 8;275:116575.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162579/TLR7-agonist-22-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162579/
Clinical Information
No Development Reported
CAS Number
3036114-68-5
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