MC4033
MC4033 shows IC50s of 39.4 μM, 52.1 μM, 41 μM and 30.1 μM in HCT116, H1299, A549 and U937, respectively[1]. MC4033 (25, 50, 100, and 200 μM, 72 h) reduces the level of H4K16Ac in HT29 cells, suggesting its ability to inhibit KAT8 in cells[1].
Product Specifications
CAS Number
[28532-21-0]
UNSPSC
12352005
Target
Apoptosis; Autophagy; Histone Acetyltransferase
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mc4033.html
Purity
98.26
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC1=NN(C2=CC=C(C=C2)C(O)=O)C(/C1=C\C3=CC=CN3)=O
Molecular Formula
C16H13N3O3
Molecular Weight
295.29
References & Citations
[1]Fiorentino F, et al. First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8. J Med Chem. 2023 May 25;66 (10) :6591-6616
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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