(D) -PPA 1 (TFA)

(D) -PPA 1 TFA is a hydrolysisresistant d-peptide antagonist. (D) -PPA 1 TFA serves as a potent PD-1/PD-L1 inhibitor. (D) -PPA 1 TFA binds to PD-1 with the affinity 0f 0.51 μM with in vitro and in vivo efficacy[1].

Product Specifications

UNSPSC

12352209

Target

PD-1/PD-L1

Type

Peptides

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/d-ppa-1-tfa.html

Purity

99.28

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H](CC4=CNC=N4)C(N[C@@H](CC5=CC=CC=C5)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC(N)=O)N.OC(C(F)(F)F)=O

Molecular Formula

C72H99F3N20O23

Molecular Weight

1669.67

References & Citations

[1]Chang HN, et al. Blocking of the PD-1/PD-L1 Interaction by a D-Peptide Antagonist for Cancer Immunotherapy. Angew Chem Int Ed Engl. 2015 Sep 28;54 (40) :11760-4.